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The craniofacial complex is one of the most vital and intricate organ systems with vast structural variation across vertebrate species. Yet, most of the structures of the craniofacial complex—cartilage, bone, neurons—are derived from the same multipotent population of neural crest cells. Specific gene regulatory networks and signaling cascades spatiotemporally orchestrate the complicated processes of neural crest development and differentiation of different derivatives. But how are these gene networks and pathways precisely activated or repressed during this complex process? Chromatin remodelers and epigenetic regulators add a level of hierarchy to crucial gene expression events. Using neural crest development and formation of craniofacial derivatives across two different vertebrate species, the Shull lab seeks to disentangle the multifaceted functions of chromatin remodelers and epigenetic regulators during key developmental processes.

Lab Philosophy

We believe that our unique identities, experiences, and backgrounds are fundamental to bringing new ideas and perspectives to the lab bench. We foster an inclusive and welcoming research environment by promoting a cohesive learning group where all identities are respected and appreciated. We are committed to building a safe and equitable space where all individuals can thrive and become inspired, creative, critically thoughtful, well-rounded scientists.