Publications

Shull LC, Artinger KB. Epigenetic regulation of craniofacial development and disease. Birth Defects Res. 2024 Jan;116(1):e2271. doi: 10.1002/bdr2.2271. Epub 2023 Nov 14. Review. PubMed PMID: 37964651; NIHMSID:NIHMS1941140.

Truong BT, Shull LC, Lencer E, Bend EG, Field M, Blue EE, Bamshad MJ, Skinner C, Everman D, Schwartz CE, Flanagan-Steet H, Artinger KB. PRDM1 DNA-binding zinc finger domain is required for normal limb development and is disrupted in split hand/foot malformation. Dis Model Mech. 2023 Apr 1;16(4). doi: 10.1242/dmm.049977. Epub 2023 Apr 21. PubMed PMID: 37083955; PubMed Central PMCID: PMC10151829.

Shull LC, Lencer ES, Kim HM, Goyama S, Kurokawa M, Costello JC, Jones K, Artinger KB. PRDM paralogs antagonistically balance Wnt/β-catenin activity during craniofacial chondrocyte differentiation. Development. 2022 Feb 15;149(4). doi: 10.1242/dev.200082. Epub 2022 Feb 24. PubMed PMID: 35132438; PubMed Central PMCID: PMC8918787.

Shull LC, Sen R, Menzel J, Goyama S, Kurokawa M, Artinger KB. The conserved and divergent roles of Prdm3 and Prdm16 in zebrafish and mouse craniofacial development. Dev Biol. 2020 May 15;461(2):132-144. doi: 10.1016/j.ydbio.2020.02.006. Epub 2020 Feb 8. PubMed PMID: 32044379; PubMed Central PMCID: PMC7198358.

Sen R, Pezoa SA, Carpio Shull L, Hernandez-Lagunas L, Niswander LA, Artinger KB. Kat2a and Kat2b Acetyltransferase Activity Regulates Craniofacial Cartilage and Bone Differentiation in Zebrafish and Mice. J Dev Biol. 2018 Nov 12;6(4). doi: 10.3390/jdb6040027. PubMed PMID: 30424580; PubMed Central PMCID: PMC6315545.

Hwang SM, Feigenson M, Begun DL, Shull LC, Culley KL, Otero M, Goldring MB, Ta LE, Kakar S, Bradley EW, Westendorf JJ. Phlpp inhibitors block pain and cartilage degradation associated with osteoarthritis. J Orthop Res. 2018 May;36(5):1487-1497. doi: 10.1002/jor.23781. Epub 2017 Nov 28. PubMed PMID: 29068480; PubMed Central PMCID: PMC5985222.

Feigenson M, Shull LC, Taylor EL, Camilleri ET, Riester SM, van Wijnen AJ, Bradley EW, Westendorf JJ. Histone Deacetylase 3 Deletion in Mesenchymal Progenitor Cells Hinders Long Bone Development. J Bone Miner Res. 2017 Dec;32(12):2453-2465. doi: 10.1002/jbmr.3236. Epub 2017 Sep 18. PubMed PMID: 28782836; PubMed Central PMCID: PMC5732041.

Carpio LR, Bradley EW, Westendorf JJ. Histone deacetylase 3 suppresses Erk phosphorylation and matrix metalloproteinase (Mmp)-13 activity in chondrocytes. Connect Tissue Res. 2017 Jan;58(1):27-36. doi: 10.1080/03008207.2016.1236088. Epub 2016 Sep 23. PubMed PMID: 27662443; PubMed Central PMCID: PMC5609188.

Carpio LR, Bradley EW, McGee-Lawrence ME, Weivoda MM, Poston DD, Dudakovic A, Xu M, Tchkonia T, Kirkland JL, van Wijnen AJ, Oursler MJ, Westendorf JJ. Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling. Sci Signal. 2016 Aug 9;9(440):ra79. doi: 10.1126/scisignal.aaf3273. PubMed PMID: 27507649; PubMed Central PMCID: PMC5409103.

Carpio LR, Westendorf JJ. Histone Deacetylases in Cartilage Homeostasis and Osteoarthritis. Curr Rheumatol Rep. 2016 Aug;18(8):52. doi: 10.1007/s11926-016-0602-z. Review. PubMed PMID: 27402109.

Bradley EW, Carpio LR, McGee-Lawrence ME, Castillejo Becerra C, Amanatullah DF, Ta LE, Otero M, Goldring MB, Kakar S, Westendorf JJ. Phlpp1 facilitates post-traumatic osteoarthritis and is induced by inflammation and promoter demethylation in human osteoarthritis. Osteoarthritis Cartilage. 2016 Jun;24(6):1021-8. doi: 10.1016/j.joca.2015.12.014. Epub 2015 Dec 31. PubMed PMID: 26746148; PubMed Central PMCID: PMC4875839.

McGee-Lawrence ME, Carpio LR, Schulze RJ, Pierce JL, McNiven MA, Farr JN, Khosla S, Oursler MJ, Westendorf JJ. Hdac3 Deficiency Increases Marrow Adiposity and Induces Lipid Storage and Glucocorticoid Metabolism in Osteochondroprogenitor Cells. J Bone Miner Res. 2016 Jan;31(1):116-28. doi: 10.1002/jbmr.2602. Epub 2015 Aug 20. PubMed PMID: 26211746; PubMed Central PMCID: PMC4758691.

Bradley EW, Carpio LR, van Wijnen AJ, McGee-Lawrence ME, Westendorf JJ. Histone Deacetylases in Bone Development and Skeletal Disorders. Physiol Rev. 2015 Oct;95(4):1359-81. doi: 10.1152/physrev.00004.2015. Review. PubMed PMID: 26378079; PubMed Central PMCID: PMC4600951.

Kourtidis A, Ngok SP, Pulimeno P, Feathers RW, Carpio LR, Baker TR, Carr JM, Yan IK, Borges S, Perez EA, Storz P, Copland JA, Patel T, Thompson EA, Citi S, Anastasiadis PZ. Distinct E-cadherin-based complexes regulate cell behaviour through miRNA processing or Src and p120 catenin activity. Nat Cell Biol. 2015 Sep;17(9):1145-57. doi: 10.1038/ncb3227. Epub 2015 Aug 24. PubMed PMID: 26302406; PubMed Central PMCID: PMC4975377.

Bradley EW, Carpio LR, Newton AC, Westendorf JJ. Deletion of the PH-domain and Leucine-rich Repeat Protein Phosphatase 1 (Phlpp1) Increases Fibroblast Growth Factor (Fgf) 18 Expression and Promotes Chondrocyte Proliferation. J Biol Chem. 2015 Jun 26;290(26):16272-80. doi: 10.1074/jbc.M114.612937. Epub 2015 May 7. PubMed PMID: 25953896; PubMed Central PMCID: PMC4481226.

Bradley EW, Carpio LR, Olson EN, Westendorf JJ. Histone deacetylase 7 (Hdac7) suppresses chondrocyte proliferation and β-catenin activity during endochondral ossification. J Biol Chem. 2015 Jan 2;290(1):118-26. doi: 10.1074/jbc.M114.596247. Epub 2014 Nov 11. PubMed PMID: 25389289; PubMed Central PMCID: PMC4281714.

McGee-Lawrence ME, Carpio LR, Bradley EW, Dudakovic A, Lian JB, van Wijnen AJ, Kakar S, Hsu W, Westendorf JJ. Runx2 is required for early stages of endochondral bone formation but delays final stages of bone repair in Axin2-deficient mice. Bone. 2014 Sep;66:277-86. doi: 10.1016/j.bone.2014.06.022. Epub 2014 Jun 25. PubMed PMID: 24973690; PubMed Central PMCID: PMC4125446.

Ryan ZC, Craig TA, Salisbury JL, Carpio LR, McGee-Lawrence M, Westendorf JJ, Kumar R. Enhanced prostacyclin formation and Wnt signaling in sclerostin deficient osteocytes and bone. Biochem Biophys Res Commun. 2014 May 23;448(1):83-8. doi: 10.1016/j.bbrc.2014.04.092. Epub 2014 Apr 26. PubMed PMID: 24780398; PubMed Central PMCID: PMC4052706.

McGee-Lawrence ME, Ryan ZC, Carpio LR, Kakar S, Westendorf JJ, Kumar R. Sclerostin deficient mice rapidly heal bone defects by activating β-catenin and increasing intramembranous ossification. Biochem Biophys Res Commun. 2013 Nov 29;441(4):886-90. doi: 10.1016/j.bbrc.2013.10.155. Epub 2013 Nov 6. PubMed PMID: 24211207; PubMed Central PMCID: PMC3876417.

Bradley EW, Carpio LR, Westendorf JJ. Histone deacetylase 3 suppression increases PH domain and leucine-rich repeat phosphatase (Phlpp)1 expression in chondrocytes to suppress Akt signaling and matrix secretion. J Biol Chem. 2013 Apr 5;288(14):9572-9582. doi: 10.1074/jbc.M112.423723. Epub 2013 Feb 13. PubMed PMID: 23408427; PubMed Central PMCID: PMC3617261.